English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Purpose  To optimize the direct production of  68 Ga on a cyclotron, via the  68 Zn(p,n) 68 Ga reaction using a liquid cyclotron target. We Investigated the yield of cyclotron-produced  68 Ga, extraction of [ 68 Ga]GaCl 3  and subsequent [ 68 Ga]Ga-PSMA-11 labeling using an automated synthesis module.    Methods  Irradiations of a 1.0 M solution of [ 68 Zn]Zn(NO 3 ) 2  in dilute (0.2–0.3 M) HNO 3  were conducted using GE PETtrace cyclotrons and GE  68 Ga liquid targets. The proton beam energy was degraded to a nominal 14.3 MeV to minimize the co-production of  67 Ga through the  68 Zn(p,2n) 67 Ga reaction without unduly compromising  68 Ga yields. We also evaluated the effects of varying beam times (50–75 min) and beam currents (27–40 μA). Crude  68 Ga production was measured. The extraction of [ 68 Ga]GaCl 3  was performed using a 2 column solid phase method on the GE FASTlab Developer platform. Extracted [ 68 Ga]GaCl 3  was used to label [ 68 Ga]Ga-PSMA-11 that was intended for clinical use.    Results  The decay corrected yield of  68 Ga at EOB was typically > 3.7 GBq (100 mCi) for a 60 min beam, with irradiations of [ 68 Zn]Zn(NO 3 ) 2  at 0.3 M HNO 3.  Target/chemistry performance was more consistent when compared with 0.2 M HNO 3 . Radionuclidic purity of  68 Ga was typically > 99.8% at EOB and met the requirements specified in the European Pharmacopoeia (< 2% combined  66/67 Ga) for a practical clinical product shelf-life. The activity yield of [ 68 Ga]GaCl 3  was typically > 50% (~ 1.85 GBq, 50 mCi); yields improved as processes were optimized. Labeling yields for [ 68 Ga]Ga-PSMA-11 were near quantitative (~ 1.67 GBq, 45 mCi) at EOS. Cyclotron produced [ 68 Ga]Ga-PSMA-11 underwent full quality control, stability and sterility testing, and was implemented for human use at the University of Michigan as an Investigational New Drug through the US FDA and also at the Royal Prince Alfred Hospital (RPA).    Conclusion  Direct cyclotron irradiation of a liquid target provides clinically relevant quantities of [ 68 Ga]Ga-PSMA-11 and is a viable alternative to traditional  68 Ge/ 68 Ga generators.

Cyclotron-based production of 68Ga, [68Ga]GaCl3, and [68Ga]Ga-PSMA-11 from a liquid target