English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Recent large-scale genome-wide association studies (GWAS) have showed that the neuronal calcium signaling has pivotal roles in schizophrenia (SCZ) in populations of European of ancestry. However, it is not known if calcium signaling pathway genes are also associated with SCZ in Han Chinese population.    Methods  Here we investigated the association between genetic variants in three calcium signaling pathway genes ( CACNB2 ,  CACNA1C  and  CACNA1I ) and SCZ in 1615 SCZ cases and 1597 controls.    Results  A single nucleotide polymorphism (SNP) (rs4522708) in  CACNA1I  is significantly associated with SCZ in our Chinese sample (OR A allele  = 1.19, corrected  P  = 0.042), suggesting that  CACNA1I  may also be a risk gene for SCZ in Chinese population. Of note, the risk allele (A allele) of SNP rs4522708 is same in European and Chinese populations. Meta-analysis of Chinese and European samples further strengthened the association of rs4522708 with SCZ (OR A allele  = 1.074,  P  = 6.26 × 10 −11 ). Expression analysis showed that  CACNA1I  was significantly up-regulated in hippocampus of SCZ cases compared with controls, implying that dysregulation of  CACNA1I  may have a role in schizophrenia pathogenesis.    Conclusions  Our study suggests that  CACNA1I  is a risk gene for SCZ in Chinese population and provides further evidence that supports the potential role of neuronal calcium signaling in schizophrenia.

Further evidence for the genetic association between CACNA1I and schizophrenia