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Background  Wound healing has being extensively investigated over the world. Healing impairment is caused by many reasons including increasing of free-radicals-mediated damage, delaying in granulation tissue formation, reducing in angiogenesis and decreasing in collagen reorganization. These facts consequently lead to chronic wound healing.  Piper betle  Linn ( Betle ) leaves have been folklore used as an ingredient of drugs for cutaneous wound treatment. However, the effect of  betle leaf  on wound healing is not yet well elucidated. In this study, we aimed to investigate the healing efficacy of methanol leaf extract of  Piper betle  Linn on proliferation of fibroblast NIH3T3 cells as well as full-thickness burn and excision wounds in swiss mice.    Methods  Scratch wound healing assays were conducted to examine the effects of  betle  leaf extract on healing activity of fibroblast cells. Burn and excision wounds on swiss mouse skins were created for investigating the wound healing progress caused by the  betle  leaf extract. Malondialdehyde (MDA) was also evaluated to examine the products of lipid hydroperoxide (LPO) under conditions of with or without  betle  leaf extract treatment.    Results  The results of this study showed that  Piper betle  Linn leaf extract in methanol increased proliferation of NIH3T3 cells and promoted wound healing  in vitro  and  in vivo  with both burn wound and excision wound models. In addition, this extract significant decreased level of malondialdehyde (MDA) in liver of treated-mice compared with that in non-treated mice.    Conclusions  Our results suggest that  Piper betle  Linn can be used as an ingredient in developing natural origin drugs for treatment of cutaneous wounds.

Influence of phytochemicals in piper betle linn leaf extract on wound healing