English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Rheumatoid arthritis (RA) is the most common autoimmune system diseases in our world. More studies in recent years have shown that  FCRL  gene polymorphisms is closely related to autoimmune diseases. It is suggested that genetic factors play a crucial role in the pathogenesis of this disease. In this study, we aimed to investigate the relationship between  FCRL1  rs2050568,  FCRL3  rs2317230 and  FCRL6  rs58240276 polymorphisms and RA risk in the Chinese Han population. 506 with RA patients and 509 healthy controls were recruited in this study, and the single nucleotide polymorphisms (SNPs) was successfully genotyped using the Agena MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (95% CIs) after adjusting for age and gender were conducted to assess these SNPs polymorphisms and RA risk. The multifactor dimensionality reduction (MDR) method was conducted to analyze SNP-SNP interaction.    Results  Our results revealed that there no significant association was observed between the allele and genotype frequencies among these SNPs and RA risk (all  p  > 0.05). Straified analysis by age and gender, the results confirmed that  FCRL1  rs2050568 T/T genotype enhanced the risk of RA in females ( p  = 0.014). The G/T - T/T genotype of  FCRL3  rs2317230 was correlated with a decreased RA risk in males ( p  = 0.021). We also observed that the C/T-T/T genotype of  FCRL6  rs58240276 was increased the risk of RA in the group at age >  54 years ( p  = 0.016). In addition,  FCRL1  rs2050568-TT,  FCRL6  rs58240276-TT and  FCRL1  rs2050568-TT,  FCRL3  rs2317230-TT,  FCRL6  rs58240276-TT are the best models for multi-site MDR analysis ( p  < 0.05), and the two best models mentioned above and classes RA have the most significant correlation.    Conclusions  Our study demonstrated that  FCRL1  rs2050568,  FCRL3  rs2317230, and  FCRL6  rs58240276 polymorphisms were correlated with RA susceptibility in the Chinese Han population.    Supplementary Information  The online version contains supplementary material available at 10.1186/s41021-021-00213-2.

Fc receptor-like 1, 3, and 6 variants are associated with rheumatoid arthritis risk in the Chinese Han population