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Gliomas are the most common primary tumors of the central nervous system, around 70 % of the malignant brain tumors are gliomas. In the NCCN Guideline Ver.1 2015, the assessment before systemic treatment, treatment principles and prognosis factors of gliomas has significantly changed based on the researches up to date, we try to analyze the reason and the effect of these changes. The most important change is the reintroduction of PCV chemotherapy in systemic treatment, which narrows the gap of prognosis between WHO II and III gliomas. Other changes including the assessment before systemic treatment, usage of RT and the promotion of evidence level about the Tumor Treating Fields.

The analysis to the latest changes in NCCN Guidelines of Central Nervous System Cancers about low-grade gliomas and glioblastoma