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Background Medicinal plants play a significant role in the progress of persuasive therapeutic agents. Earlier to the innovation of synthetic drugs, human beings completely relied on the plants for the treatment of various ailments. Natural product extracts, particularly those derived from different plant species, provided the main source of Siddha, Ayurveda and Folk medicines.  P. daemia  is a perennial climber, traditionally reported for the treatment in a variety of diseases. In present review, we focused on the present status of phytochemical and pharmacological activities  P. daemia . Methodology With the support of electronic databases such as Science Direct, Google Scholar, Mendeley, Scirus and PubMed central. Traditional knowledge information collected by Indian taxonomical books, survey from local rural and tribal peoples. Pharmacological data’s obtained from scientific journals published from 2000 to 2020. Results P. daemia  extract, contains several phytochemicals, especially rich in flavonoids. These secondary metabolites synthesized from  P. daemia  have been reported for the treatment of various chronic diseases. In recent years,  P. daemia  phytoconstituents set as a key role in natural drug development as it harbours many in vitro and in vivo pharmacological activities such as anti-inflammatory, anti-cancer, anti-fertility, anti-arthritic and antimicrobial etc., Conclusion P. daemia  was the less studied plant compared to other medicinal plants. In this context more emphasis has to be laid on studies that discuss on the secondary metabolite activities and molecular mechanisms that work against various chronic diseases.

Active status on phytochemistry and pharmacology of Pergularia daemia Forsk. (Trellis-vine): a review