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Background Nowadays, the green synthesis of AuNPs in the presence of plants has been attracted a lot of attention. Herein, in vivo antidiabetic activity of AuNPs synthesized using Ziziphus jujuba in streptozotocin-induced diabetic rats has been evaluated. Methods Formation of AuNPs was confirmed by UV-vis, HR-TEM and XRD. Different doses of jujube gold nanoparticles (0.5 and 1 mg/kg) were used to treat streptozotocin-induced diabetic rats in different groups. At the end of experiment (21 days), serum level of fasting blood glucose (FBG), insulin, Body weight, HOMA-IR, vitamin D, ALT, AST, urea, creatinine, lipid profile, prooxidant-antioxidant balance (PAB) and liver oxidative stress markers were determined. Results results showed a significant decrease in the level of liver MDA ( P  = 0.001), fasting blood glucose ( P  = 0.0001), HOMA-IR ( P  = 0.0001), ALT ( P  = 0.0001), AST ( P  = 0.0001), urea ( P  = 0.02), Triglycerides ( P  = 0.002), Total cholesterol ( P  = 0.0001), PAB ( P  = 0.0001) and AIP ( P  = 0.001) and in contrast a significant increase total antioxidant capacity ( P  = 0.02), insulin ( P  = 0.03), Body weight ( P  = 0.0001) and vitamin D ( P  = 0.0001) in the AuNPs-treated diabetic group compared to the diabetic rats. No significant change was observed in the total thiol group ( P  = 0.18), LDL-C ( P  = 0.43), creatinine ( P  = 0.09) and HDL-C ( P  = 0.71) level in diabetic rats treated with AuNPs compared to diabetic rats. Conclusion The results of this study proves that green AuNPs exerted promising antidiabetic and anti-oxidant properties.

clinical phytoscience

Anti-dyslipidemic properties of green gold nanoparticle: improvement in oxidative antioxidative balance and associated atherogenicity and insulin resistance