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BackgroundDennettia tripetala is a medicinal plant with in vitro antioxidant activities. It is capable of protecting the liver and kidney of rats from damage when administered prior to a single exposure of carbon tetrachloride. The aim of this study was to document the possible ameliorative effect of the aqueous extract of Dennettia tripetala fruits on rats subjected to multiple exposures of carbon tetrachloride.MethodsCarbon tetrachloride was administered orally to male albino rats of Wistar strain four times over a 2 week period. The aqueous extract of Dennettia tripetala fruits was administered daily for 7 days starting on the 8th day after carbon tetrachloride administration had commenced.ResultsCarbon tetrachloride caused increases in serum ALT, AST and ALP, serum total cholesterol, serum LDL-cholesterol, liver total cholesterol and triglyceride, serum total protein, globulin, urea, creatinine as well as liver and kidney malondialdehyde levels. Carbon tetrachloride also caused significant reductions in serum HDL-cholesterol, serum triglyceride, serum albumin:globulin ratio as well as liver and kidney SOD and catalase activities. The plant extract was able to restore the biochemical parameters to levels comparable to those of the control group in all instances. Further evidence in support of these results was derived from histopathological analysis.ConclusionTaken together, the results of this study show that the aqueous extract of Dennettia tripetala fruits is able to ameliorate liver and kidney damage caused by multiple exposures to carbon tetrachloride probably via an antioxidant-dependent mechanism.

Aqueous extract of Dennettia tripetala ameliorates liver and kidney damage caused by multiple exposures to carbon tetrachloride