English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  The heightened prevalence of  Salmonella  Typhimurium remains a public health and food safety concern. Studies have reported antibiotic, flavophospholipol, may have the ability to reduce  Salmonella  in swine, as well as alter the gut microbiota in favour of beneficial bacteria by inhibiting pathogenic bacteria. Thus, the objective of this study was to investigate the fecal microbiota of weaned pigs receiving in-feed flavophospholipol and challenged with  Salmonella  Typhimurium.    Results  Twenty-one weaned pigs were fed either a diet containing 4 ppm of flavophospholipol (treatment group) or a non-medicated feed (control group) for 36 days post-weaning (Day 1 to Day 36). The pigs were orally challenged with a 2 mL dose of 10 8  CFU/mL of  S.  Typhimurium at Day 7 and Day 8. Community bacterial DNA extracted from fecal samples collected at Day 6 (before challenge) and Day 36 (28 days after challenge) were used to assess the fecal microbiota using the V4 region of the 16S rRNA gene with Illumina MiSeq next-generation sequencing. Sequencing data were visualized using mothur and analyzed in JMP and R software. The fecal microbiota of pigs in the treatment group had differences in abundance of phyla (Firmicutes, Proteobacteria) and genera ( Lactobacillus, Roseburia ,  Treponema,  unclassified Ruminococcaceae,  Blautia ,  Streptococcus ,  Megasphaera ,  Dorea ,  Sporobacter ,  Peptococcus , unclassified Firmicutes,  Clostridium  IV and  Campylobacter)  when compared to pigs that were controls, 28 days after challenge with  Salmonella  ( P  < 0.05). Specifically, results demonstrated a significant increase in phylum Proteobacteria ( P =  0.001) and decrease in Firmicutes ( P  = 0.012) and genus  Roseburia  ( P  = 0.003) in the treated pigs suggestive of possible microbial dysbiosis. An increased abundance of genera  Lactobacillus  ( P  = 0.012) was also noted in the treated group in comparison to the control.    Conclusion  Based on these findings, it is difficult to conclude whether treatment with 4 ppm of flavophospholipol is promoting favorable indigenous bacteria in the pig microbiota as previous literature has suggested.

Effect of flavophospholipol on fecal microbiota in weaned pigs challenged with Salmonella Typhimurium