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Background  Increased performance from injury prevention exercise programmes (IPEPs) may affect injury risks positively and support the implementation of IPEPs. The primary aim was to study the performance effects of injury prevention exercises from two different IPEPs, the  Knee Control  IPEP and the further developed  Knee Control+  IPEP, in youth male football players, and the secondary aim was to compare potential differences in performance effects between the IPEPs.    Methods  Four male youth football teams were tested for agility, hop and sprint performance at the start of the second half of the competitive season and after the end of the 8-week season. Per randomisation, two teams used  Knee Control  and two teams  Knee Control+ .    Results  In total, 47 players executed a median of 13 IPEP sessions (range 11–21 sessions). No improvements in performance were seen in the group as a whole. The intervention groups showed small declines in sprint and agility performance. There was a significant between-group difference in change for the 505 agility test, with improved performance in the  Knee Control  and worse performance in the  Knee Control+  group, Δ KC vs KC+  = − 0.012 (95% CI − 0.19 to −0.04),  d  = 0.98.    Conclusions  No clinically meaningful performance effects were seen from the  Knee Control  or  Knee Control+  IPEP in youth male athletes and no meaningful differences were seen between  Knee Control  and  Knee Control+  regarding effects on performance tests.    Trial registration   ClinicalTrials.gov  identifier:  NCT03251404 . Registered on 16 August 2017.

Performance Effects with Injury Prevention Exercise Programmes in Male Youth Football Players: A Randomised Trial Comparing Two Interventions