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Background  To evaluate the effect of vitamin D supplementation on C-reactive protein (CRP) through a systematic review and meta-analysis of randomized control trials (RCTs).    Methods  PubMed-Medline, SCOPUS, Google Scholar and Web of Science databases were searched (up until April 2016) to identify RCTs evaluating the impact of vitamin D supplementation on CRP. We used random effects models (using DerSimonian-Laird method) as well as the generic inverse variance methods for quantitative data synthesis. For sensitivity analysis, we applied leave-one-out approach. To examine the heterogeneity we used I2 index. Registration code: CRD42016036932.    Results  Among 1274 search items ,  24 studies met the inclusion criteria in the final evaluation. Pooling the data together indicated a non-significant decrease in CRP level following administration of vitamin D (weighted mean difference [WMD] -0.26(mg/l), (95% CI -0.75 to 0.22,  N  = 26 arms, heterogeneity  p  = 0.042; I 2  54.2%). The WMDs for IL6 was 0.67 pg/ml, (95% CI 0.29 to 1.06,  N  = 16 arms, heterogeneity  p  = 0.234; I 2  19.1%), 0.43 pg/ml, (95% CI 0.08 to 1.05,  N  = 26 arms, heterogeneity  p  = 0.120; I 2  42.1%), for IL10, and −0.11 pg/ml, (95% CI -0.53 to 0.30,  N  = 12 arms, heterogeneity  p  = 0.423; I 2  9.2%) for TNF-α, 4.03 pg/ml, (95% CI 3.50 to 4.57,  N  = 3 arms, heterogeneity  p  = 0.752; I 2  8.1%) for adiponectin. Sensitivity analyses confirmed the robustness of the findings.    Conclusions  This study provided evidence that vitamin D supplementation had no impact on serum CRP, IL10, and TNF-α, while significantly increased serum IL6. We recommend RCTs with longer period of follow-up time (12 months) for future studies to provide explicit results.    Electronic supplementary material  The online version of this article (10.1186/s40795-017-0207-6) contains supplementary material, which is available to authorized users.

Impact of vitamin D supplementation on C-reactive protein; a systematic review and meta-analysis of randomized controlled trials