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Staphylococcus aureus  is a versatile Gram-positive coccus frequently found colonizing the skin and nasal membranes of humans. The acquisition of the staphylococcal cassette chromosome  mec  was a major milestone in the evolutionary path of methicillin-resistant  S. aureus . This genetic element carries the  mecA  gene, the main determinant of methicillin resistance. MRSA is involved in a plethora of opportunistic infectious diseases. The accessory gene regulator is the major  S. aureus  quorum sensing system, playing an important role in staphylococcal virulence, including the development of biofilms. We report the complete genome sequence (NCBI BioProject ID: PRJNA264181) of the methicillin-resistant  S. aureus  strain GV69 (= CMVRS P4521), a variant of the ST239 lineage that presents with a natural attenuation of  agr -RNAIII transcription and a moderate accumulation of biofilm.   Electronic supplementary material  The online version of this article (doi:10.1186/s40793-016-0154-x) contains supplementary material, which is available to authorized users.

standards in genomic sciences

Complete genome sequence of an agr-dysfunctional variant of the ST239 lineage of the methicillin-resistant Staphylococcus aureus strain GV69 from Brazil