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The present study demonstrates that the down-regulation of peroxisome proliferator-activated receptor-α (PPARα) results in chronic low ambient temperature (LT) exposure-induced cardiac dysfunction and remodeling, emphasizing the therapeutic potential of PPARα activation strategies (e.g. fenofibrate treatment) in LT-associated cardiac injury.   Supplementary Information  The online version contains supplementary material available at 10.1186/s40779-021-00347-y.

Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling