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The IL-32 cytokine family is associated with chronic inflammatory diseases such as Chronic Obstructive Pulmonary Disease. However, this unique family is comprised of several alternative splicing isoforms and their expression pattern or responses to inflammatory stimuli are unclear. We aimed to determine which IL-32 isoforms are expressed in various cell types and in chronic airway disease, as well as their response to inflammatory stimuli.

IL-32B is the predominant isoform expressed under inflammatory conditions in vitro and in COPD