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Background  To explore the usefulness of analyzing histograms and textures of apparent diffusion coefficient (ADC) maps and T2-weighted (T2W) images to differentiate prostatic cancer (PCa) from benign prostatic hyperplasia (BPH) using histopathology as the reference.    Methods  Ninety patients with PCa and 112 patients with BPH were included in this retrospective study. Differences in whole-lesion histograms and texture parameters of ADC maps and T2W images between PCa and BPH patients were evaluated using the independent samples t-test. The diagnostic performance of ADC maps and T2W images in being able to differentiate PCa from BPH was assessed using receiver operating characteristic (ROC) curves.    Results   The mean, median, 5 th , and 95 th  percentiles of ADC values in images from PCa patients were significantly lower than those from BPH patients ( p  < 0.05). Significant differences were observed in the means, standard deviations, medians, kurtosis, skewness, and 5 th  percentile values of T2W image between PCa and BPH patients ( p  < 0.05). The ADC 5th  showed the largest AUC (0.906) with a sensitivity of 83.3 % and specificity of 89.3 %. The diagnostic performance of the T2W image histogram and texture analysis was moderate and had the largest AUC of 0.634 for T2W Kurtosis  with a sensitivity and specificity of 48.9% and 79.5 %, respectively. The diagnostic performance of the combined ADC 5th  & T2W Kurtosis  parameters was also similar to that of the ADC 5th  & ADC Diff−Variance .    Conclusions  Histogram and texture parameters derived from the ADC maps and T2W images for entire prostatic lesions could be used as imaging biomarkers to differentiate PCa and BPH biologic characteristics, however, histogram parameters outperformed texture parameters in the diagnostic performance.

cancer imaging

Differentiating prostate cancer from benign prostatic hyperplasia using whole-lesion histogram and texture analysis of diffusion- and T2-weighted imaging