English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Kirsten rat sarcoma viral oncogene homolog ( KRAS ) and epidermal growth factor receptor ( EGFR ) are the two most frequent and well-known oncogene of lung adenocarcinoma. The purpose of this study is to compare the characteristics measured with dual-energy spectral computed tomography (DESCT) in lung adenocarcinoma patients who have  KRAS  and  EGFR  gene mutations.    Methods  Patients with surgically resected lung adenocarcinoma ( n  = 72) were enrolled, including 12 patients with  KRAS  mutations and 60 patients with  EGFR  mutations. DESCT quantitative parameters, including the CT number at 70 keV, the slopes of the spectral attenuation curves (slope λ HU), normalized iodine concentration (NIC), normalized water concentration (NWC), and effective atomic number (effective Z), were analyzed. A multiple logistic regression model was applied to discriminate clinical and DESCT characteristics between the types of mutations.    Results  The  KRAS  mutation was more common in people who smoked than the  EGFR  mutation. Nodule type differed significantly between the  KRAS  and  EGFR  groups ( P  = 0.035), and all  KRAS  mutation adenocarcinomas were solid nodules. Most DESCT quantitative parameters differed significantly between solid nodules and subsolid nodules. CT number at 70 keV, slope λ HU, NIC, and effective Z differed significantly between the  KRAS  and  EGFR  groups ( P  = 0.006, 0.017 ,  0.013 and 0.010) with solid lung adenocarcinoma. Multivariate logistic analysis of DESCT and clinical features indicated that besides smoking history, the CT value at 70 keV (OR = 0.938,  P  = 0.009) was significant independent factor that could be used to differentiate  KRAS  and  EGFR  mutations in solid lung adenocarcinoma.    Conclusions  DESCT would be a potential tool to differentiate lung adenocarcinoma patients with a  KRAS  mutation from those with an  EGFR  mutation.

cancer imaging

Dual-energy spectral CT characteristics in surgically resected lung adenocarcinoma: comparison between Kirsten rat sarcoma viral oncogene mutations and epidermal growth factor receptor mutations