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Purpose  To identify clinically relevant magnetic resonance imaging (MRI) features of different types of metastatic brain lesions, including standard anatomical, diffusion weighted imaging (DWI) and dynamic susceptibility contrast (DSC) perfusion MRI.    Methods  MRI imaging was retrospectively assessed on one hundred and fourteen ( N  = 114) brain metastases including breast ( n  = 27), non-small cell lung cancer (NSCLC,  n  = 43) and ‘other’ primary tumors ( n  = 44). Based on 114 patient’s MRI scans, a total of 346 individual contrast enhancing tumors were manually segmented. In addition to tumor volume, apparent diffusion coefficients (ADC) and relative cerebral blood volume (rCBV) measurements, an independent component analysis (ICA) was performed with raw DSC data in order to assess arterio-venous components and the volume of overlap (AVOL) relative to tumor volume, as well as time to peak (TTP) of T 2 * signal from each component.    Results  Results suggests non-breast or non-NSCLC (‘other’) tumors had higher volume compare to breast and NSCLC patients ( p  = 0.0056 and  p  = 0.0003, respectively). No differences in median ADC or rCBV were observed across tumor types; however, breast and NSCLC tumors had a significantly higher “arterial” proportion of the tumor volume as indicated by ICA ( p  = 0.0062 and  p  = 0.0018, respectively), while a higher “venous” proportion were prominent in breast tumors compared with NSCLC ( p  = 0.0027) and ‘other’ lesions ( p  = 0.0011). The AVOL component was positively related to rCBV in all groups, but no correlation was found for arterial and venous components with respect to rCBV values. Median time to peak of arterial and venous components were 8.4 s and 12.6 s, respectively ( p  < 0.0001). No difference was found in arterial or venous TTP across groups.    Conclusions  Advanced ICA-derived component analysis demonstrates perfusion differences between metastatic brain tumor types that were not observable with classical ADC and rCBV measurements. These results highlight the complex relationship between brain tumor vasculature characteristics and the site of primary tumor diagnosis.    Electronic supplementary material  The online version of this article (10.1186/s40644-019-0201-0) contains supplementary material, which is available to authorized users.

Probabilistic independent component analysis of dynamic susceptibility contrast perfusion MRI in metastatic brain tumors