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Background  To investigate the associations between the diffusion parameters obtained from multiple-b-values diffusion weighted imaging (DWI) of pancreatic ductal adenocarcinoma (PDAC) and the aggressiveness and local stage prediction, and assess the values of the quantitative parameters for the discrimination of tumors from healthy pancreas.    Methods  Fifty-one patients with surgical pathology-proven PDAC (size, 35 ± 12 mm) and fifty-seven healthy volunteers were enrolled. Diffusion parameters including monoexponential apparent diffusion coefficient (ADC b  and ADC total ) and biexponential intravoxel incoherent motion (IVIM) parameters (ADC slow , ADC fast  and f) based on 9 b-values (0 to 1000s/mm 2 ) DWI were calculated for the lesions and the healthy pancreas. These parameters were compared by grades of differentiation, lymph node status, tumor stage and location. The diagnostic performances were calculated and compared by using the receiver operating characteristic curves (ROC) analyses.    Results  There was no statistically significant difference in ADC b , ADC total , ADC slow , ADC fast  or f between PDAC stage T1/T2 and stage T3/T4 or moderately differentiated versus poorly differentiated PDAC ( p  = 0.060-0.941). In addition, no significant differences were observed for the quantitative parameters between tumors located in the pancreatic head versus other pancreatic regions ( p =  0.203-0.954) or between tumors with and without metastatic peri-pancreatic lymph nodes ( p =  0.313-0.917). ADC 25-600 , ADC 1000 , ADC total  and ADC fast  were significantly lower for PDAC compared the healthy pancreas (all p < 0.05). ROC analyses showed the area under curve for ADC 20  was the largest (0.911) to distinguish PDAC from normal pancreas (cut-off value, 5.58 × 10 −3 mm 2 /s) and had the highest combined sensitivity (89.5%) and specificity (82.4%).    Conclusions  Multiple-b-values DWI derived monoexponential and biexponential parameters of PDAC do not exhibit significance dependence on tumor grade or tumor characteristics. ADC 20  provided the best accuracy for differentiating PDAC from healthy pancreas in the study.

cancer imaging

Intravoxel incoherent motion DWI of the pancreatic adenocarcinomas: monoexponential and biexponential apparent diffusion parameters and histopathological correlations