English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Although anthrax immune globulin (AIG) improved survival in antibiotic-treated Bacillus anthracis-challenged animal models, whether it adds to the benefit of conventional hemodynamic support for  B. anthracis  toxin-associated shock is unknown.    Methods  We therefore tested AIG in sedated, mechanically ventilated canines challenged with 24-h B. anthracis lethal and edema toxin infusions and supported for 96 h with a previously demonstrated protective regimen of titrated normal saline and norepinephrine.    Results  Compared to controls, proportional survival (%) was increased with AIG treatment started 4 h before (33 vs. 100%,  n  = 6 each) or 2 h (17 vs. 86%,  n  = 6 and 7 respectively) or 5 h (0 vs. 67%,  n  = 3 each) after the start of toxin ( p  ≤ 0.05) and overall [3 survivors of 15 controls (20%) vs. 14 of 16 AIG animals (88%);  p  = 0.006]. Averaged across treatment times, AIG increased blood pressure at 48 h and decreased norepinephrine requirements at 72 h ( p  ≤ 0.02), increased left ventricular ejection fraction at 48 and 72 h ( p  ≤ 0.02), and increased urine output and decreased net fluid balance at 72 and 96 h ( p  ≤ 0.04). AIG also reduced acidosis and renal and hepatic injury markers between 24 and 96 h.    Conclusions  These findings further support AIG’s potential benefit for patients with  B .  anthracis  infection and developing toxin-associated shock.    Electronic supplementary material  The online version of this article (10.1186/s40635-017-0159-9) contains supplementary material, which is available to authorized users.

intensive care medicine experimental

Anthrax immune globulin improves hemodynamics and survival during B. anthracis toxin-induced shock in canines receiving titrated fluid and vasopressor support