English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Cnidarian venoms and extracts have shown a broad variety of biological activities including cytotoxic, antibacterial and antitumoral effects. Most of these studied extracts were obtained from sea anemones or jellyfish. The present study aimed to determine the toxic activity and assess the antitumor and antiparasitic potential of  Palythoa caribaeorum  venom by evaluating its in vitro toxicity on several models including human tumor cell lines and against the parasite  Giardia intestinalis .    Methods  The presence of cytolysins and vasoconstrictor activity of  P. caribaeorum  venom were determined by hemolysis, PLA 2  and isolated rat aortic ring assays, respectively. The cytotoxic effect was tested on HCT-15 (human colorectal adenocarcinoma), MCF-7 (human mammary adenocarcinoma), K562 (human chronic myelogenous leukemia), U251 (human glyoblastoma), PC-3 (human prostatic adenocarcinoma) and SKLU-1 (human lung adenocarcinoma). An in vivo toxicity assay was performed with crickets and the antiparasitic assay was performed against  G. intestinalis  at 24 h of incubation.    Results   P. caribaeorum  venom produced hemolytic and PLA 2  activity and showed specific cytotoxicity against U251 and SKLU-1 cell lines, with approximately 50% growing inhibition. The venom was toxic to insects and showed activity against  G. intestinalis  in a dose-dependent manner by possibly altering its membrane osmotic equilibrium.    Conclusion  These results suggest that  P. caribaeorum  venom contains compounds with potential therapeutic value against microorganisms and cancer.

Hemolytic, anticancer and antigiardial activity of Palythoa caribaeorum venom