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Background  Jorge Lobo’s disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus  Lacazia loboi . Herein we report a study that relates the genotoxicity caused by  L. loboi  in isogenic mice with nutritional status, through a normal or restricted diet.    Methods  DNA damage was assessed in the peripheral blood by the comet assay (tail intensity).    Results  The results for leukocytes showed increases in the mean tail intensity in mice under dietary restriction, in infected mice under dietary restriction and in infected mice ingesting a normal diet.    Conclusion  These results indicate that dietary restriction and  L. loboi  infection may increase DNA damage levels in mice, as detected by the comet assay.

DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status