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Background   Acinetobacter baumannii  is an opportunistic pathogen that can cause several kinds of nosocomial infections. Increasing antibiotic resistance as well as identifying genetic diversity and factors associated with pathogenicity and prevalence of this bacterium is important. The aim of this study was the investigation of molecular typing, biofilm production, and detection of carbapenemase genes in multidrug-resistant  Acinetobacter baumannii  isolated from different infection sites using ERIC-PCR in Iran.    Methods  Forty isolates of  A. baumannii  were obtained from various wards of the central hospital, in the west of Iran. Phenotypic identification and genetic diversity, biofilm production assay, and detection of Carbapenemase genes carried out.    Results  Tracheal samples 26 (61.9 %) are the most frequent isolates, and 95 % of isolates were identified as MDR. 32.5 % of all  A. baumannii  strains were capable to form a strong biofilm. It was founded that antimicrobial resistance patterns had a significant relationship with strong biofilm formation ( P  = 0.001). Most frequencies of the studied genes were in the order of  VIM  (81 %),  SPM  (45.2 %), and  IMP  (35.7 %) genes. The  VIM  gene was the most frequent in all isolates which were significant ( P  = 0.006). 14 different ERIC-types were observed including 7 common types and 7 unique or single types. F type is the largest common type consisting of nine isolates and B, D, and E types contain two isolates separately.    Conclusions  ERIC-PCR technique was used to genetically classify  A. baumannii  isolates as one of the most common microorganisms in nosocomial infections.

bmc pharmacology and toxicology

Molecular typing, biofilm production, and detection of carbapenemase genes in multidrug-resistant Acinetobacter baumannii isolated from different infection sites using ERIC-PCR in Hamadan, west of Iran