English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The clinical diagnosis of trichinellosis is difficult because its clinical manifestations are nonspecific. Detection of anti- Trichinella  IgG by ELISA using  T. spiralis  muscle larval excretory-secretory (ES) antigens is the most commonly used serological method for diagnosis of trichinellosis, but the main disadvantage is false negativity during the early stage of infection. There is an obvious window period between  Trichinella  infection and antibody positivity.  During the intestinal stage of  Trichinella  infection, the ES antigens of intestinal worms (intestinal infective larvae and adults) are exposed to host’s immune system at the earliest time and elicit the production of specific anti- Trichinella  antibodies. Anti- Trichinella  IgG antibodies in infected mice were detectable by ELISA with ES antigens of intestinal worms as soon as 8–10 days post infection (dpi), but ELISA with muscle larval ES antigens did not permit detection of infected mice before 12 dpi. Therefore, the new early antigens from  T. spiralis  intestinal worms should be screened, identified and characterized for early serodiagnosis of trichinellosis.   Electronic supplementary material  The online version of this article (doi:10.1186/s40249-017-0252-z) contains supplementary material, which is available to authorized users.

New insights on serodiagnosis of trichinellosis during window period: early diagnostic antigens from Trichinella spiralis intestinal worms