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Background  The polymorphism of Interleukin 1 receptor antagonist gene ( IL-1RN ), which encodes a natural antagonist of pro-inflammatory cytokines belonging to IL-1 family and Haptoglobin ( HP ) have been studied in various ethnic groups in association with Type 2 Diabetes Mellitus (T2DM) risk and related complications. However, there was no study available among the Emirati population. Hence, we designed a combined study on  IL-1RN  and  HP  polymorphism to evaluate their association with prevalence of T2DM, related complication and hypertension and also its interaction with obesity status among Emirati population.    Methods    IL-1RN  and  HP  genotypes were determined in total 487 Emiratis divided in two groups of T2DM case ( n  = 271) and healthy controls ( n  = 215) by polymerase chain reaction (PCR) followed by gel electrophoresis. Gene-gene interaction and polymorphism-obesity interaction were determined by multivariate logistic regression analysis.    Results  We found that the frequencies of  IL-1RN*1/*1  and  HP2-2  genotypes were significantly higher in cases than control and were associated with increased T2DM risk with an odds ratio (OR) of 1.60 (95 % CI 1.10–2.36) and 1.63 (95 % CI 1.11–2.64), respectively. The association lack any interaction with obesity status. Associations with occurrences of T2DM related complications and hypertension were not observed.    Conclusions  We report an association of  IL-1RN  and  HP  polymorphism with T2DM risk independent of each other and of obesity status but no association with related complications and hypertension.    Electronic supplementary material  The online version of this article (doi:10.1186/s40200-016-0232-z) contains supplementary material, which is available to authorized users.

journal of diabetes and metabolic disorders

Combined association analysis of interleukin 1-receptor antagonist (IL-1RN) variable number of tandem repeat (VNTR) and Haptoglobin 1/2 polymorphisms with type 2 diabetes mellitus risk