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Objective  To explore the correlation of mutation landscape with clinical outcomes in patients with peripheral T-cell lymphoma (PTCL).    Methods  We retrospectively analyzed the clinicopathological and prognosis data of 53 patients with PTCL from November 2011 to December 2017. Targeted next-generation sequencing of a 659-gene panel was performed for tissues from 53 patients with PTCLs. The correlation of mutation landscape with clinical outcomes was analyzed.    Results   TET2  was the most frequently mutated gene (64%), followed by  RHOA  (43%),  PCLO  (23%),  DNMT3A  (19%),  IDH2  (17%),  PIEZO1  (17%) and  TP53  (15%). When mutated genes were categorized into functional groups, the most common mutations were those involved in epigenetic/chromatin modification (75%), T-cell activation (74%), and the DNA repair/TP53 pathway (64%).  TET2/TP53  mutations were significantly associated with positive B symptoms ( P  = 0.045), and elevated lactate dehydrogenase (LDH) level ( P  = 0.011). Moreover,  TET2/TP53  mutation was a risk factor for PTCL patient survival (HR 3.574, 95% CI 1.069 − 11.941,  P  = 0.039). The occurrence of JAK/STAT pathway mutations in angioimmunoblastic T-cell lymphoma (AITL) patients conferred a worse progression-free survival (HR 2.366, 95% CI 0.9130–6.129,  P  = 0.0334).    Conclusions  Heterogeneous gene mutations occur in PTCL, some of which have a negative impact on the survival outcome.

Correlation of mutational landscape and survival outcome of peripheral T-cell lymphomas