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Background Dietary supplementation with a fucoidan-rich  Ascophyllum nodosum  extract (ANE), possessing an in vitro anti- Salmonella  Typhimurium activity could be a promising on-farm strategy to control  Salmonella  infection in pigs. The objectives of this study were to: 1) evaluate the anti- S.  Typhimurium activity of ANE (containing 46.6% fucoidan, 18.6% laminarin, 10.7% mannitol, 4.6% alginate) in vitro, and; 2) compare the effects of dietary supplementation with ANE and Zinc oxide (ZnO) on growth performance,  Salmonella  shedding and selected gut parameters in naturally infected pigs. This was established post-weaning (newly weaned pig experiment) and following regrouping of post-weaned pigs and experimental re-infection with  S.  Typhimurium (challenge experiment). Results In the in vitro assay, increasing ANE concentrations led to a linear reduction in  S.  Typhimurium counts ( P    0.05). ANE supplementation decreased the Enterobacteriaceae counts compared to the control. Enterobacteriaceae counts were also reduced in the ZnO-residual group compared to the control ( P  &lt;  0.05). ANE supplementation decreased the expression of interleukin 22 and transforming growth factor beta 1 in the ileum compared to the control ( P  &lt;  0.05). Conclusions ANE supplementation was associated with some beneficial changes in the composition of the colonic microbiota,  Salmonella  shedding, and the expression of inflammatory genes associated with persistent  Salmonella  infection.

journal of animal science and biotechnology/journal of animal science and biotechnology

Potential of a fucoidan-rich Ascophyllum nodosum extract to reduce Salmonella shedding and improve gastrointestinal health in weaned pigs naturally infected with Salmonella