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Background  Seaweed-derived polysaccharides (SDP) represent an attractive source of prebiotic nutraceuticals for the food and animal husbandry industry. However, the mechanism by which SDP from  Enteromorpha  mediates pig growth are not fully understood. This study aimed to investigate how SDP supplementation influences the growth performance and intestinal health in weaned pigs.    Results  In Exp. 1, 240 weaned pigs were randomly assigned to four dietary treatments and fed with a basal diet or a basal diet containing 200, 400 or 800 mg/kg SDP, respectively, in a 21-day trial. Pigs on the 400 or 800 mg/kg SDP-supplemented group had greater ADG and lower F/G ratio than those on the control group ( P <0.05). In Exp. 2, 20 male weaned pigs were randomly assigned to two treatments and fed with a basal diet (CON group) or a basal diet supplemented with 400 mg/kg SDP (the optimum does from Exp. 1), in a 21-day trial. Pigs fed the SDP diet had greater ADG, the concentrations of serum IL-6 and TNF-α and the activities of glutathione peroxidase, superoxide dismutase and catalase ( P <0.05), and lower F/G, diarrhea rate, as well as serum  D -lactate concentrations and diamine oxidase activity ( P <0.05). Moreover, dietary SDP supplementation enhanced secretory immunoglobulin A content, villus height and villous height: crypt depth ratio in small intestine, as well as the lactase and maltase activities in jejunum mucosa ( P <0.05). SDP supplementation elevated the mRNA levels of inflammatory response-related genes ( IL-6 ,  TNF-α ,  TLR4 ,  TLR6  and  MyD88 ), and the mRNA and protein levels of ZO-1, claudin-1 and occludin in jejunum mucosa ( P <0.05). Importantly, SDP not only increased the  Lactobacillus  population but also reduced the  Escherichia coli  population in cecum ( P <0.05). Furthermore, SDP increased acetic acid and butyric acid concentrations in cecum ( P <0.05).    Conclusions  These results not only suggest a beneficial effect of SDP on growth performance and intestinal barrier functions, but also offer potential mechanisms behind SDP-facilitated intestinal health in weaned pigs.

journal of animal science and biotechnology/journal of animal science and biotechnology

Dietary seaweed-derived polysaccharides improve growth performance of weaned pigs through maintaining intestinal barrier function and modulating gut microbial populations