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Background  Probiotics are used as a means to improve animal health and intestinal development.  Saccharomyces boulardii  is a well-known probiotic; however, few studies have examined the effects of  S. boulardii  on weaned piglet performance. Therefore, this 28-day study compared the effects of  S. boulardii  mafic-1701 and aureomycin in diets for weaned piglets on growth performance, antioxidant parameters, inflammation and intestinal microbiota. One hundred and eight piglets, weaned at 28 d of age (8.5 ± 1.1 kg), were randomly divided into the three dietary treatment groups with six pens and six piglets per pen (half male and half female). The dietary treatment groups were as follows: 1) basal diet (CON); 2) basal diet supplemented with 75 mg/kg aureomycin (ANT); 3) basal diet supplemented with 1 × 10 8  CFU/kg  S. boulardii  mafic-1701 (SB).    Results  Compared to CON group, SB group had higher feed efficiency ( P  < 0.05) in the last 14 d and lower diarrhea rate ( P  <  0.05) over the entire 28 d. Total superoxide dismutase in serum was markedly increased in SB group ( P  < 0.05). Moreover, compared with CON group, SB group decreased the levels of pro-inflammatory cytokines interleukin-6 ( P  <  0.01) and Tumor necrosis factor-α ( P  < 0.05) in jejunum. Supplementation of  S. boulardii  mafic-1701 increased the abundance of  Ruminococcaceae_UCG_009  and  Turicibacter  ( P  < 0.05), whereas the abundance of unclassified _Clostridiaceae_4  was decreased ( P  < 0.05). Furthermore,  S. boulardii  mafic-1701 administration increased cecal concentration of microbial metabolites, isobutyrate and valerate ( P  < 0.05).    Conclusions  The improvement in feed conversion ratio, reduction in diarrhea rate in weaned piglets provided diets supplemented with  S. boulardii  mafic-1701 may be associated with enhanced antioxidant activity, anti-inflammatory responses and improved intestinal microbial ecology.

journal of animal science and biotechnology/journal of animal science and biotechnology

Administration of Saccharomyces boulardii mafic-1701 improves feed conversion ratio, promotes antioxidant capacity, alleviates intestinal inflammation and modulates gut microbiota in weaned piglets