English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Limited research has focused on the effect of  Lactobacillus  on the intestinal toxicity of deoxynivalenol (DON). The present study was conducted to investigate the role of  Lactobacillus plantarum (L. plantarum)  JM113 in protecting against the intestinal toxicity caused by DON.    Methods  A total of 144 one-day-old healthy Arbor Acres broilers were randomly distributed into 3 treatments, including the CON (basal diet), the DON (extra 10 mg/kg deoxynivalenol), and the DL (extra 1 × 10 9  CFU/ kg  L. plantarum  JM113 based on DON group) treatments. The growth performance, organ indexes, intestinal morphology, pancreatic digestive enzymes, intestinal secreted immunoglobulin A (sIgA), jejunal transcriptome, and intestinal microbiota were evaluated.    Results  Compared with the CON and DL groups, the DON supplementation altered intestinal morphology, especially in duodenum and jejunum, where villi were shorter and crypts were deeper ( P  < 0.05). Meanwhile, the significantly decreased mRNA expression of jejunal claudin-1 and occludin ( P  < 0.05), ileal  rBAT  and jejunal  GLUT1  of 21-day-old broilers ( P  < 0.05), as well as duodenal  PepT1  and ileal  rBAT  of 42-day-old broilers were identified in the DON group. Moreover, supplementation with  L. plantarum  JM113 could increase duodenal expression of  IL-10  and  IL-12  of 21-day-old broilers, ileal sIgA of 42-day-old broilers, and the bursa of Fabricius index of 21-day-old broilers. Further jejunal transcriptome proved that the genes related to the intestinal absorption and metabolism were significantly reduced in the DON group but a significant increase when supplemented with extra  L. plantarum  JM113. Furthermore, the bacteria related to nutrient utilization, including the Proteobacteria,  Escherichia ,  Cc-115 (P  < 0.05 ) ,  Lactobacillus  and  Prevotella  ( P  < 0.1) were all decreased in the DON group. By contrast, supplementation with  L. plantarum  JM113 increased the relative abundance of beneficial bacterium, including the Bacteroidetes,  Roseburia ,  Anaerofustis ,  Anaerostipe , and  Ruminococcus bromii  ( P  < 0.05). Specifically, the increased abundance of bacteria in the DL group could be proved by the significantly increased caecal content of propionic acid, n-Butyric acid, and total short-chain fatty acid.    Conclusions   L. plantarum  JM113 enhanced the digestion, absorption, and metabolic functions of the gut when challenged with DON by reducing the injury to intestinal barriers and by increasing the abundance of beneficial bacterium.    Electronic supplementary material  The online version of this article (10.1186/s40104-018-0286-5) contains supplementary material, which is available to authorized users.

journal of animal science and biotechnology/journal of animal science and biotechnology

Intestinal toxicity of deoxynivalenol is limited by supplementation with Lactobacillus plantarum JM113 and consequentially altered gut microbiota in broiler chickens