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Toll-interacting protein (Tollip) is a mediator involved in the TLRs signaling pathway which is critical for innate immune response. In the present study, a full-length Tollip cDNA was first cloned from common carp ( Cc Tollip), which was 1284 bp in length, containing an open reading frame of 831 bp encoding a peptide of 276 amino acids. Multiple sequence alignment showed that the  Cc Tollip shared the highest similarity with that of grass carp and zebrafish. Phylogenetically, the  Cc Tollip clustered together well with their piscine family members. Quantitative real-time PCR analysis indicated that  Cc Tollip was widely expressed in all tissues tested and showed up-regulation with challenges of  Vibrio anguillarum  and poly(I:C), suggesting that  Cc Tollip was activated by  V. anguillarum  and poly(I:C). These data indicated that  Cc Tollip might play an important role in immune response to bacterial and viral invasion.   Electronic supplementary material  The online version of this article (doi:10.1186/s40064-016-2293-3) contains supplementary material, which is available to authorized users.

Characterization and expression analysis of Toll-interacting protein in common carp, Cyprinus carpio L., responding to bacterial and viral challenge