English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Focal segmental glomerulosclerosis (FSGS) is a major cause of renal failure. Sera of some FSGS patients increase glomerular albumin permeability (P alb ) during in vitro testing and cause proteinuria in experimental animals.    Objectives  To determine whether permeability activity of FSGS serum (P alb  activity) is associated with rate of progression to renal replacement therapy (RRT).    Design  This is an observational study based on medical and demographic information and P alb  activity testing.    Setting  Studies were performed at Medical College of Wisconsin.    Patients  Serum was submitted by patients’ nephrologists for measurement of P alb  activity. Each patient had had a biopsy diagnosis of FSGS, had reached ESRD and was on dialysis or had a functioning transplant.    Measurements  P alb  activity, clinical characteristics and time between biopsy diagnosis and RRT (T-RRT) were recorded for each patient.    Methods  P alb  activity was measured using established in vitro techniques.    Results  P alb  and T-RRT were inversely correlated. Neither P alb  nor T-RRT varied with demographics or medications. Kaplan–Meier survival curves showed that patients with P alb  ≥ 0.5 progressed to RRT more rapidly than others.    Limitations  Only patients who had reached RRT were included. Limited clinical information was available for each patient. Central verification of biopsy characteristics was not performed and detailed descriptions of renal histology were not available.    Conclusions  P alb  activity is associated with the rate of progression to RRT in patients with FSGS. Additional observations will be needed to verify that P alb  activity predicts prognosis and is useful in stratifying patients for clinical decision making or treatment trials.

Serum glomerular albumin permeability activity: association with rapid progression to end-stage renal disease in focal segmental glomerulosclerosis