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Sandal ( Santalum album L ) contains several interesting amino acids and amines which are not seen in other plants. This includes  cis -4-hydroxy- l -proline in free form in leaves, flowers and seeds while  trans -4-hydroxy- l -proline in bound form. Traces of 3, 4 dehydroproline is also detected in sandal leaves. Biosynthesis of  cis -4-hydroxy proline indicates that hydroxylation taken place at proline present in peptidyl form especially bound to glutamic acid and aspartic acid. Pyrrolizidine-2-carboxylic acid an interesting isatin positive heterocyclic compound is also present in sandal leaves. Sandal also contains  sym . homospermidine which is not present in any other plants till today. Biosynthesis of  sym . homospermidine goes by a unique pathway of putrescine oxidation, Schiff base formation, condensation and reduction. Moreover sandal leaves contain γ-glutamyl derivative of the lachrymatory precursor of onion, γ-glutamyl-S-propenyl cysteine superoxide. This review summarizes the studies on the amino acids in sandal.

Amino acids in sandal (Santalum album L) with special reference to cis-4-hydroxy-l-proline and sym. homospermidine