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Human immunodeficiency virus-1 (HIV-1) which causes acquired immune deficiency syndrome (AIDS), by infecting CD4 +  immune cells and hence weakening the host defense mechanism till death, is one of the major factor responsible for human demises worldwide. Both innate (monocytes and macrophages) and adaptive (T cells) immune cells expresses chemokines receptors (2 and 5) and stromal cell derived factor-1 ( SDF - 1 ) which play crucial role in HIV-1 virus entry and progression. Allele variants of genes  CCR5  ( CCR5 - Δ32 ),  CCR2  ( CCR2 - 64I ) and  SDF1  ( SDFA - 3 ′ A ; the ligand of  CXCR4 ) are known to slow down the HIV-1 progression in infected individual. In the present study, the frequency of  CCR5 - Δ32, CCR2 - 64I  and  SDF1 - 3 ′ A  alleles in primitive tribe (Baiga) and a non-primitive tribe (Gond) of central India were investigated. A total 200 seronegative samples for HIV from healthy individuals of tribes were analyzed and observed allele frequencies of  CCR5 - Δ32, CCR2 - 64I  and  SDF1 - 3 ′ A  were (0, 0.035, 0.080) and (0, 0.110, 0.100) in Baiga and Gond respectively. Minor allele frequency of these alleles of Gond and Baiga tribes were compared with different populations of the world for relative hazard (RH), which indicate the risk of progression after infection of HIV1. The RH values were calculated based on genotypic frequency, showed the high RH value (RH1-AIDS1993-0.98, RH2-AIDS1987-0.98 and death/RH3-0.97) in Baiga tribe, indicates the low level of resistance against HIV-1 progression after infection.   Electronic supplementary material  The online version of this article (doi:10.1186/s40064-015-1238-6) contains supplementary material, which is available to authorized users.

Low prevalence of CCR5-Δ32, CCR2-64I and SDF1-3′A alleles in the Baiga and Gond tribes of Central India