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The effects of onion peel extract (OPE) in collagen (5 μg/mL)-stimulated washed rat platelet aggregation were investigated. OPE inhibited platelet aggregation  via  inhibition of aggregation-inducing molecules, intracellular Ca 2+  and thromboxane A 2  (TXA 2 ) by blocking cyclooxygenase-1 (COX-1) and TXA 2  synthase (TXAS) activities in a dose-dependent manner. In addition, OPE elevated the formation of cyclic adenosine monophosphate (cAMP), aggregation-inhibiting molecule, but not cyclic guanosine monophosphate (cGMP). High performance liquid chromatography (HPLC) analysis of OPE revealed that OPE contains quercetin, one of the major flavonoids, which has anti-platelet effect. In conclusion, we suggest that OPE is an effective inhibitor of collagen-stimulated platelet aggregation  in vitro . Therefore, it can be a promising and safe strategy for anti-cardiovascular diseases.

Onion (Allium cepa L.) peel extract has anti-platelet effects in rat platelets