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Interleukin 18 (IL18) is a kind of proinflammatory cytokine that belongs to the interleukin-1 family. IL18 is associated with obesity and type 2 diabetes. To discover whether body composition parameters in IL18 deficient mouse are altered in single-housed condition, body weight, glucose tolerance, lipid profiles, fat masses, and size of white adipocytes were examined. Mice were housed singly and were divided as follows: C57BL/6 J male (B6-M), IL18 deficient male (IL18-M), C57BL/6 J female (B6-F), IL18 deficient female (IL18-M). Body weight statistically significantly increased in IL18-M at 9 months (p < 0.05). Glucose tolerance occurred in IL18-M at 6 and 9 months. Total cholesterol and HDL cholesterol were statistically significantly increased in IL18-F compared with B6-F at 9 and 12 months, respectively (p < 0.05). Also, total cholesterol of IL18-M was statistically significantly increased compared with B6-F and IL18-F at 9 months (p < 0.05). The perirenal and inguinal fat masses were statistically significantly increased in IL18-M at 9 months (p < 0.05). In addition, the size of white adipocytes was increased in IL18-M at 9 months. In single-housed condition, onset of obesity and glucose tolerance were delayed by 3 months in IL18-M. Taken together, these results suggest that housing condition is a very important factor for weight gain and onset of glucose tolerance in IL18 deficient male mouse.

Delayed onset of obesity and glucose tolerance in interleukin 18 deficient mice by single housed condition