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Background  Carbapenemase-producing  K. pneumoniae  (CP-Kp) has been established as important nosocomial pathogen in most tertiary care hospitals in Greece. The aim of the present study was to examine the impact of an enhanced infection control program on the containment of CP-Kp in a haematology unit where the incidence of CP-Kp infections was high.    Methods  The study was conducted from June 2011 to December 2014 in a haematology unit of a tertiary-care 500-bed hospital located in Athens, Greece. A bundled intervention (active surveillance cultures, separation of carriers from non-carriers, assignment of dedicated nursing staff, contact precautions, environmental cleaning, and promotion of hand hygiene) was tested whether would reduce colonization and infection caused by CP-Kp.    Results  A total of 2507 rectal swabs were obtained; 1199 upon admission from June 2011 to June 2013 and 1307 during hospitalization from June 2011 to December 2012. During intervention the admission prevalence of CP-Kp colonization ( p  &lt; 0.001 for linear trend), the hospitalization prevalence ( p  = 0.001 for linear trend) and the incidence rate of CP-Kp colonization ( p  = 0.072 for linear trend) were declining. Application of segmented linear regression revealed that both the change in the level of CP-Kp BSI incidence rates ( p  = 0.001) as well as the difference between pre- and post-intervention slopes were statistically significant ( p  &lt; 0.001).    Conclusions  A bundled intervention including active surveillance cultures on admission can attain maximum containment of CP-Kp colonization and infection in endemic acute healthcare settings.

Containing Carbapenemase-producing Klebsiella pneumoniae in an endemic setting