English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Antimicrobial resistance in multidrug-resistant  Acinetobacter baumannii  (MDR-AB) isolated from burn wound infections is a major concern in intensive care or burns units worldwide, and molecular studies are considered critical strategies for control of MDR-AB outbreaks in this regard. Thus, in this study, antibiotic resistance, biofilm-forming ability, molecular epidemiology of MDR  A. baumannii  strains recovered from patients with burns were investigated in three major hospital centers of Iran.    Methods  In this cross-sectional research, 163 non-repetitive  A. baumannii  strains were tested for susceptibility to antimicrobial agents. Polymerase chain reaction (PCR) was performed to characterize ambler classes A, B, and D β-lactamases, IS Aba1  and integrons, biofilm formation was also investigated. Clonal relatedness was analyzed using Pulsed-Field Gel Electrophoresis (PFGE).    Results  Among 163  A. baumannii  strains collected, 94.5% of them were Carbapenem-Non-Susceptible  A. baumannii  (CNSAB) and also 90.1 and 52.2% of them were Metallo-β-Lactamases (MBL) and Extended-Spectrum β-Lactamases (ESBL) producing isolates, respectively. Colistin and polymyxin B exhibited excellent activity against CNSAB strains. High prevalence of  bla  OXA − 23-like  (85.1%),  bla  VIM  (60.5%),  bla  PER − 1  (42.3%),  tetB  (67.8%), and Class 1 integrons (65.6%) were identified in CNSAB strains. IS Aba1  element was associated with 42 (25.8%) and 129 (98.5%) of  bla  OXA-51-like  and  bla  OXA-23-like  genes, respectively. 6 clusters with the ability to form strong biofilms were found to be dominant and endemic in our entire areas.    Conclusions  Results of the present study show that antimicrobial resistance in CNSAB isolates from burn wound infections in monitored hospitals in Iran is multifactorial, and also findings of the study suggested that local antibiotic prescription policies should be regularly reviewed, and efficient infection control measures should be observed. Therefore, further strengthening of surveillance of antimicrobial resistance is urgently needed in these regions.

antimicrobial resistance and infection control

Study of genetic diversity, biofilm formation, and detection of Carbapenemase, MBL, ESBL, and tetracycline resistance genes in multidrug-resistant Acinetobacter baumannii isolated from burn wound infections in Iran