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Treating  M. abscessus  infection is challenging due to the potent β-lactamase Bla Mab  (Beta-lactamase of  M. abscessus  ) . Avibactam is a non-β-lactam, β-lactamase inhibitor shown to inhibit Bla Mab . We tested whether avibactem can render piperacillin effective against  M. Abscessus . In-vitro, avibactam enhanced the activity of piperacillin by 16–32 fold, with no significant effect on meropenem. In an in-vivo  Galleria mellonella  model, meropenem and piperacillin/avibactam significantly decreased infection burden compared to untreated controls. Neither piperacillin nor avibactam alone had a significant effect.

The addition of avibactam renders piperacillin an effective treatment for Mycobacterium abscessus infection in an in vivo model