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Background  The bactericidal effect of disinfectants against biofilms is essential to reduce potential endoscopy-related infections caused by contamination. Here, we investigated the bactericidal effect of a high-level disinfectant, peracetic acid (PAA), against  Staphylococcus aureus  and  Pseudomonas aeruginosa  biofilm models in vitro.    Methods    S. aureus  and  P. aeruginosa  biofilms were cultured at 35 °C for 7 days with catheter tubes. The following high-level disinfectants (HLDs) were tested: 0.3% PAA, 0.55% ortho-phthalaldehyde (OPA), and 2.0% alkaline-buffered glutaraldehyde (GA). Biofilms were exposed to these agents for 1–60 min and observed after 5 min and 30 min by transmission and scanning electron microscopy. A Student’s  t  test was performed to compare the exposure time required for bactericidal effectiveness of the disinfectants.    Results  PAA and GA were active within 1 min and 5 min, respectively, against  S. aureus  and  P. aeruginosa  biofilms. OPA took longer than 10 min and 30 min to act against  S. aureus  and  P. aeruginosa  biofilms, respectively ( p  < 0.01). Treatment with PAA elicited changes in cell shape after 5 min and structural damage after 30 min.    Conclusions  Amongst the HLDs investigated, PAA elicited the most rapid bactericidal effects against both biofilms. Additionally, treatment with PAA induced morphological alterations in the in vitro biofilm models, suggesting that PAA exerts fast-acting bactericidal effects against biofilms associated with endoscopy-related infections. These findings indicate that the exposure time for bactericidal effectiveness of HLDs for endoscope reprocessing in healthcare settings should be reconsidered.

antimicrobial resistance and infection control

Morphological bactericidal fast-acting effects of peracetic acid, a high-level disinfectant, against Staphylococcus aureus and Pseudomonas aeruginosa biofilms in tubing