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Background  Antimicrobial resistance has emerged as a major threat to global public health. Thus, the surveillance of changes in antimicrobial resistance in local and global settings is a paramount necessity. While many studies have tracked antimicrobial resistance, only a small percentage surveyed ocular isolates. The purpose of this study was to report the in vitro susceptibility of bacterial pathogens isolated from ocular samples in New York, NY from 2010 to 2015.    Methods  A retrospective review of ocular isolates was conducted. All organisms were collected by 25 separate inpatient wards and outpatient clinics, and were analyzed by the clinical microbiology laboratory at Mount Sinai Hospital. Clinical Laboratory and Standards Institute (CLSI) guidelines were followed for susceptibility testing and breakpoint interpretations.    Results  A total of 549 bacterial organisms were isolated from 1664 cultures (33%) during the 6-year study period. Of these, 358 isolates (65.2%) underwent susceptibility testing. 182 (50.8%) isolates were Gram-positive. The most common Gram-positive bacterium was  Staphylococcus aureus  (62.1%). Methicillin-resistance decreased in  S. aureus  isolates (31.3% in 2010, 14.1% in 2015) but was without significant change ( p  = 0.25). When analyzing all  S. aureus  isolates recovered during the study period, there were significantly more methicillin-resistant  S. aureus  (MRSA) isolates resistant to fluoroquinolones ( p  <0.0001), erythromycin ( p  <0.0001), and trimethoprim/sulfamethoxazole (TMP/SMZ;  p  <0.05). Overall,  Streptococcus pneumoniae  isolates showed reduced susceptibility to erythromycin, but were otherwise susceptible to the other antimicrobials tested.  Haemophilus influenzae  (26.1%) and  Pseudomonas aeruginosa  (23.9%) were the most common Gram-negative bacteria isolated .  Resistance to ampicillin and TMP/SMZ was observed in several of the  H. influenzae  isolates.  P. aeruginosa  isolates did not show high resistance overall, however, it was noted that isolates resistant to meropenem were also resistant to other antimicrobials ( p  < 0.01).    Conclusion  Overall, antimicrobial resistance was infrequent for the Gram-negative and Gram-positive bacteria analyzed. While the MRSA isolates demonstrated increased resistance to multiple antimicrobial classes, this is expected for this pathogen. Due to the continued use of broad-spectrum oral and systemic antimicrobials to treat ocular infections, findings of this study and other surveillance studies specific to ocular isolates should be used as resources in effective decision making in the treatment of ocular disease.

antimicrobial resistance and infection control

Retrospective report of antimicrobial susceptibility observed in bacterial pathogens isolated from ocular samples at Mount Sinai Hospital, 2010 to 2015