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Background  Smokeless tobacco is a part of social and cultural life in Sudan. The affordability and availability of this kind of tobacco make it a fundamental issue in adolescents. The aim of this study is to investigate the extent of the use of smokeless tobacco in adolescents and its determinants.    Methods  A school-based cross-sectional study was conducted in Khartoum state in Sudan. The study targeted male and female adolescents in secondary schools. A total of 3387 students from public and private schools participated in the study. Multistage random sampling was used to select the participants. The Arabic version questionnaire from the Global Youth Tobacco Survey (GYTS) was utilised to collect the data from the participants.    Results  Among the participants, 57.3% were females and 42.7% were males. Students from private and public schools were 48.4 and 51.6%, respectively. The overall prevalence of those who had ever used smokeless tobacco was 7.6%, in which the prevalence among male students was 11.0% while among females was 5.0%. The determinant factors were male gender (OR 1.53 CI 95% 1.03–2.28), family structure (OR 1.52 CI 95% 1.03–2.23), exposure to second-hand smoke at home (OR 1.60 CI 95% 1.11–2.31), friends smoking cigarettes (OR 1.78 CI 95% 1.22–2.60), lack of restriction of selling tobacco to minors (OR 1.73 CI 95% 1.25–2.39), promotion of smokeless tobacco (OR 2.12 CI 95% 1.20–3.72) and low self-efficacy (OR 7.47 CI 95% 4.45–12.52).    Conclusion  A comprehensive prevention programme that enforces the prohibition of the promotion of smokeless tobacco and the selling of smokeless tobacco to minors is crucial. Moreover, the prevention programme should enhance adolescents’ self-efficacy.    Supplementary Information  The online version contains supplementary material available at 10.1186/s13690-021-00699-w.

Determinants of smokeless tobacco use and prevalence among Sudanese adolescents