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Background  Chronic obstructive pulmonary disease (COPD) is a heterogeneous disorder that progresses over time, and currently it is the fourth leading cause of death across the globe. The World Health Organization (WHO) predicts that the disease will become the third leading cause of death by 2030.  The present study aimed to assess the burden trends of COPD in Iran by estimating the disability-adjusted life years (DALYs) from 1995 to 2015.Methods  Data were retrospectively collected as the Global Burden of Disease (GBD) from 1995 to 2015 and published by the Institute for Health Metrics and Evaluation. We applied DALYs, incidence and prevalence rate to report the burden of COPD in Iran. To assess the statistical significance according to trend, the Cochran-Armitage test was applied.  Additionally, the t-test was used to analyze the DALYs number by gender and Onaway ANOVA by age groups at a significance level set at   P    < 0.05.Results  From 1995 to 2015, there were approximately  1.1 million DALYs  attributable to COPD in Iran. In both genders and at all ages, the number of DALYs increased significantly from  176,224  in 1995 to  253,618  in 2015. The incidence and prevalence rate were 76.65 and 1491.37 per 100,000 population, respectively in both genders in 2015 in Iran. It is noticeable that the number of deaths during the study years, 1995 to 2015, was  39,064. This study showed that the COPD burden was significantly different by age groups and gender.Conclusions   COPD is still a public health problem in Iran and has an increasing trend . The majority of DALYs were due to  the years of life lost as a result of premature death (YLLs),  indicating that prevention and early detection, especially in the age groups of 15 to 70 years, should be considered.

Trends in burden of chronic obstructive pulmonary disease in Iran, 1995–2015: findings from the global burden of disease study