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In this paper, the dynamics of a general differential equation with neutral type are investigated. Under certain assumptions, the stability of positive equilibrium and the existence of Hopf bifurcation are obtained by analyzing the distribution of eigenvalues. And global existence of positive periodic solutions is established by using the global Hopf bifurcation result of Krawcewicz et al. Finally, by taking neutral Nicholson’s blowflies model and neutral Mackey–Glass model as two examples, some numerical simulations are carried out to illustrate the analytical results.

Global existence of positive periodic solutions of a general differential equation with neutral type