English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  cRel, a subunit of NF-κB, is implicated in the inflammatory response observed in autoimmune disease. Hence, knocked-out mice for cRel had a significantly higher mortality, providing new and important functions of cRel in the physiopathology of septic shock. Whether genetic variants in the human  REL  gene are associated with severity of septic shock is unknown.    Methods  We genotyped a population of 1040 ICU patients with septic shock and 855 ICU controls for two known polymorphisms of  REL ;  REL rs842647  and  REL rs13031237 . Outcome of patients according to the presence of  REL  variant alleles was compared.    Results  The distribution of  REL  variant alleles was not significantly different between patients and controls. Among the septic shock group,  REL rs13031237*T  minor allele was not associated with worse outcome. In contrast,  REL rs842647*G  minor allele was significantly associated with more multi-organ failure and early death [OR 1.4; 95 % CI (1.02–1.8)].    Conclusion  In a large ICU population, we report a significant clinical association between a variation in the human  REL  gene and severity and mortality of septic shock, suggesting for the first time a new insight into the role of cRel in response to infection in humans.

Association of REL polymorphisms and outcome of patients with septic shock