English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Background  Endothelial progenitor cells (EPCs) have been suggested to constitute a restoration index of the disturbed endothelium in ICU patients. Neuromuscular electric stimulation (NMES) is increasingly employed in ICU to prevent comorbidities such as ICU-acquired weakness, which is related to endothelial dysfunction. The role of NMES to mobilize EPCs has not been investigated yet. The purpose of this study was to explore the NMES-induced effects on mobilization of EPCs in septic ICU patients.    Methods  Thirty-two septic mechanically ventilated patients (mean ± SD, age 58 ± 14 years) were randomized to one of the two 30-min NMES protocols of different characteristics: a high-frequency (75 Hz, 6 s on–21 s off) or a medium-frequency (45 Hz, 5 s on–12 s off) protocol both applied at maximally tolerated intensity. Blood was sampled before and immediately after the NMES sessions. Different EPCs subpopulations were quantified by cytometry markers CD34 + /CD133 + /CD45 − , CD34 + /CD133 + /CD45 − /VEGFR 2  +  and CD34 + /CD45 − /VEGFR 2  + .    Results  Overall, CD34 + /CD133 + /CD45 −  EPCs increased from 13.5 ± 10.2 to 20.8 ± 16.9 and CD34 + /CD133 + /CD45 − /VEGFR 2  +  EPCs from 3.8 ± 5.2 to 6.4 ± 8.5 cells/10 6  enucleated cells (mean ± SD,  p  < 0.05). CD34 + /CD45 − /VEGFR 2  +  EPCs also increased from 16.5 ± 14.5 to 23.8 ± 19.2 cells/10 6  enucleated cells (mean ± SD,  p  < 0.05). EPCs mobilization was not affected by NMES protocol and sepsis severity ( p  > 0.05), while it was related to corticosteroids administration ( p  < 0.05).    Conclusions  NMES acutely mobilized endothelial progenitor cells, measures of the endothelial restoration potential, in septic ICU patients.

Neuromuscular electrical stimulation acutely mobilizes endothelial progenitor cells in critically ill patients with sepsis