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Due to wide range of secondary metabolites, lichens were used from antiquity as sources of colorants, perfumes and medicaments. This research focuses on exploring the antioxidant, antimicrobial and cytotoxic activities of methanol, ethanol, acetone extracts and aqueous infusions of corticolous lichens sampled from Armenia. Methanol, ethanol and acetone extracts from all tested lichens were active against Gram-positive bacterial strains. The most effective solvent to retrieve antimicrobial compounds was methanol. Aqueous infusions of tested lichens didn’t show any significant antibacterial and antifungal activity. The highest antimicrobial activity was observed for methanol extract of  Ramalina sinensis . The minimum inhibitory concentration of methanol extract of  Ramalina sinensis  were 0.9–1.8 mg mL − 1 .  Pseudevernia furfuracea  demonstrated antifungal activity (Ø 12 mm). Methanol extract of  Parmelia sulcata  demonstrated largest 1,1-diphenyl-2-picryl-hydrazil (DPPH) radical scavenging activity (71 %). The cytotoxicity was measured on human HeLa (cervical carcinoma) cell lines using microculture tetrazolium test assay. The IC 50  values estimated for methanol extracts of  Peltigera praetextata, Evernia prunastri, Ramalina sinensis  and  Ramalina farinacea  species in HeLa cell line were within 1.8–2.8 mg mL − 1  and considered as non-cytotoxic. Obtained results suggest that studied lichens can be prospective in biotechnologies as alternative sources of antimicrobial and antioxidant substances.

Antimicrobial and antioxidant potentials of non-cytotoxic extracts of corticolous lichens sampled in Armenia