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For seeking novel antibacterial agents with high efficacy and low toxicity to deal with drug resistance, the effects of  Salvia miltiorrhizae  from various sources on  Escherichia coli  were evaluated by microcalorimetry coupled with chemometrics. Firstly, the heat-flow power-time curves of  E. coli  growth affected by different  S. miltiorrhizae  samples were recorded. Then, some crucial quantitative thermo-kinetic parameters including growth rate constant, heat-flow power and heat output, etc. were obtained from theses curves and were further investigated by some powerful chemometric techniques including similarity analysis, multivariate analysis of variance, hierarchical clustering analysis and principle component analysis. By analyzing the principle parameters, growth rate constant of the second exponential phase ( k   2 ) and the heat-flow output powers of the second highest peak ( P   2 ), together with the derived parameter inhibitory ratio ( I ,  %), it could be quickly concluded that the tested  S. miltiorrhizae  samples from different sources in China exhibited strong antibacterial effects on  E. coli  and the samples from Beijing city exhibited the strongest anti- E. coli  effects, which might be used as novel and underlying antibacterial candidates for the resistance of  E. coli  to the existing drugs in practice. This study provides a useful tool and helpful idea to accurately and rapidly evaluate the antibacterial effects of some complex matrices, offering some references for exploring new antibacterial agents.

Antibacterial evaluation of Salvia miltiorrhizae on Escherichia coli by microcalorimetry coupled with chemometrics