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Mycoplasma hyopneumoniae  is the primary agent of enzootic pneumonia in pigs. Although cell mediated immunity (CMI) may play a role in protection against  M. hyopneumoniae , its transfer from sows to their offspring is poorly characterized. Therefore, maternally-derived CMI was studied in piglets from vaccinated and non-vaccinated sows. The potential influence of cross-fostering before colostrum ingestion on the transfer of CMI from dam to piglets was also investigated. Six  M. hyopneumoniae  vaccinated sows from an endemically infected herd and 47 of their piglets, of which 24 piglets were cross-fostered, were included, as well as three non-vaccinated control sows from an  M. hyopneumoniae -free herd and 24 of their piglets. Vaccinated sows received a commercial bacterin intramuscularly at 6 and 3 weeks prior to farrowing. The TNF-α, IFN-γ and IL-17A production by different T-cell subsets in blood of sows, colostrum and blood of piglets was assessed using a recall assay. In blood of sows cytokine producing T-cells were increased upon  M. hyopneumoniae  vaccination. Similarly,  M. hyopneumoniae -specific T-cells were detected in blood of 2-day-old piglets born from these vaccinated sows. In contrast, no  M. hyopneumoniae -specific cytokine producing T-cells were found in blood of piglets from control sows. No difference was found in  M. hyopneumoniae -specific CMI between cross-fostered and non-cross-fostered piglets. In conclusion, different  M. hyopneumoniae -specific T-cell subsets are transferred from the sow to the offspring. Further studies are required to investigate the role of these transferred cells on immune responses in piglets and their potential protective effect against  M. hyopneumoniae  infections.   Supplementary Information  The online version contains supplementary material available at 10.1186/s13567-021-00968-0.

Transfer of Mycoplasma hyopneumoniae-specific cell mediated immunity to neonatal piglets