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This study was conducted to investigate the impacts of graded severity of  Eimeria maxima  infection on the growth performance and intestine health of broiler chickens. Four different levels of  E. maxima -challenged treatments were used, including a non-challenged control group, a low challenge (12 500 oocysts), a medium challenge (25 000 oocysts), and a high challenge dose (50 000 oocysts). There were eight replicate cages per treatment, with 12 birds in each cage, and chickens in the challenged groups orally received sporulated oocysts on day 14. Gastrointestinal permeability was measured by fluorescein isothiocyanate dextran at 5 days post-infection (dpi), whereas intestinal morphology and gene expression of nutrient transporters and tight junction proteins were determined at 6 dpi. The results demonstrate a linear reduction in growth performance, jejunal villus height, and jejunal integrity with graded challenge doses of  E. maxima  ( P  < 0.01). Moreover, linear regulation of nutrient transporters and tight junction proteins was a consequence of increasing  Eimeria  infection levels ( P  < 0.01). The linear increase of Claudin 1, cationic amino acid transporter, glucose transporter 1, and L-type amino acid transporter genes was associated with increased severity of coccidiosis ( P  < 0.01). Furthermore, expression of nutrient transporters located at the brush border membrane were down-regulated ( P  < 0.01) with increasing  E. maxima  inoculation dose. In conclusion, growth performance and key intestinal integrity biomarkers in broiler chickens were adversely influenced in a dose-dependent manner by  E. maxima  infection.

veterinary research

Impacts of increasing challenge with Eimeria maxima on the growth performance and gene expression of biomarkers associated with intestinal integrity and nutrient transporters