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Revealing the multifocal mechanisms affecting cross-talk between  Clostridium perfringens  pathogenesis and the host response is an urgent need in the poultry industry. Herein, the activity of  Cannabis sativa -derived cannabidiol (CBD) and selenium nanoparticles (Nano-Se) in modulating the host response to  Clostridium perfringens  challenge was investigated in broiler chickens subjected to a mild infection model. The infected chickens exhibited no clinical manifestations, confirming the potential hazard of pathogen transmission to the food chain in the commercial sector. However, both CBD and Nano-Se affected the responses of chickens to  C. perfringens  challenge. The beneficial actions of both agents were manifested in the upregulated expression of genes determining gut barrier function. Both CBD and Nano-Se promoted shifts in gut bacterial enzyme activity to increased energy uptake in challenged chickens and upregulated potential collagenase activity. There was no opposite effect of CBD and Nano-Se in mediating the host response to challenge, whereas an additive effect was evidenced on the upregulation of gene determining gut integrity. Collectively, these findings indicate that understanding the action mechanisms of CBD and Nano-Se is of great interest for developing a preventive strategy for  C. perfringens  infection in broilers.

veterinary research

Cannabis-derived cannabidiol and nanoselenium improve gut barrier function and affect bacterial enzyme activity in chickens subjected to C. perfringens challenge